Peptides and peptidomimetics as immunomodulators
نویسندگان
چکیده
منابع مشابه
Bacterial Peptides as Immunomodulators
Mucosal surfaces are habitats for the physiological microflora and are closely related to the mucosal immune compartment (mucosa-associated lymphoid tissue, MALT). Recently, considerable evidence has been accumulated showing that defined members of the physiological microflora express/liberate low molecular weight substances (peptides) which apparently are essential for the adequate immune resp...
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Helma Wennemers HW received her master (Diploma) degree in chemistry from the University of Frankfurt in 1993 and her PhD degree from Columbia University New York in 1996. After two years as a postdoctoral researcher at Nagoya University, she joined the faculty at the University of Basel where she is now associate professor of chemistry. Her research focuses on the use of peptides in supramolec...
متن کاملHigh throughput synthesis of peptides and peptidomimetics.
Peptide synthesis has been developed into one of the most efficient synthetic procedures in organic chemistry. The problems of orthogonal functional group protection and amide bond formation without racemization have been developed in a number of ingenious strategies. Optimization, in particular, has been achieved in stepwise solid phase synthesis. This in turn made possible the development of ...
متن کاملPeptides and Peptidomimetics for Antimicrobial Drug Design
The purpose of this paper is to introduce and highlight a few classes of traditional antimicrobial peptides with a focus on structure-activity relationship studies. After first dissecting the important physiochemical properties that influence the antimicrobial and toxic properties of antimicrobial peptides, the contributions of individual amino acids with respect to the peptides antibacterial p...
متن کاملPeptides and Peptidomimetics in Medicinal Chemistry
Peptides show great pharmaceutical potential as active drugs and diagnostics in several clinical areas such as endocrinology, urology, obstetrics, oncology, etc. and as functional excipients in drug delivery systems to overcome tissue and cellular membrane barriers (Nestor, 2009). From a pharmaceutical point of view, peptides are situated somewhere between classical organic drug substances and ...
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ژورنال
عنوان ژورنال: Immunotherapy
سال: 2014
ISSN: 1750-743X,1750-7448
DOI: 10.2217/imt.14.37